A Guide to AMPK Activators
AMPK is the regulator that is maintaining cellular energy homeostasis which is basically the foundation of the body’s functionality. Now in mammals, AMPK is regulating the energy balance at both on cellular level by means of sensing ATP/AMP and ATP/ADP ratio levels and whole body level through response to the hormones and the brain.
Actually, ATP is the most significant energy molecule in the body. To make it simpler, this is the point where cellular function starts. Now because of the reason that energy is used by cells, ATP breaks down into ADP that actually has got less potential for energy. ADP is then broken down to AMP which has contains the least energy potential among all 3. In reality, this is where AMPK is used; it senses the ratios of ATP/ADP/AMP and it tells the body if it requires more ADP so by that, it will be able to maintain optimal functions.
AMPK acts on various processes through different mechanisms. Since the AMPK is considered as the master regulator for all functioning cells, it just makes sense. The impact of AMPK activation in our body will depend on a complicated balance of both factors as well as signaling pathways. Even so, there are some accepted benefits of increased AMPK activation including:
Anti aging – as we age, comes along with the gradual decline of AMPK activation. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. AMPK is important because it helps in having adequate level of new mitochondria and promotes cellular renewal as well.
Anti inflammation – interestingly enough, AMPK activation can help in decreasing inflammation but it can be decreased as well by inflammation.
Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.
There are lots of herbal products/constituents and nutritional products too that are proven to be effective as AMPK activator and few of these are:
Number 1. AICAR – this is the analog of AMP which is needed in cellular use and storage similar to ATP. AICAR has been studied and discovered to directly affect AMPKs activity that helps it to improve muscle performance all because it’s the analog of AMP.
Number 2. ALA – ALA or in this case, Alpha Lipoic Acid is not just an effective antioxidant but also, a powerful AMPK activator. This has been uncovered to have anti obesity effect and can increase insulin sensitivity.
Number 3. Green tea extract – this helps in activating upstream kinase which then helps in activating AMPK.
Number 4. Berberine – with AMPK activation, berberine was known to bring the same anti diabetic effect as metformin.